Helical Chirality of Ferrocene Moieties in Cyclic Ferrocene?Peptide Conjugates

Ferrocene has been utilized as an organometallic scaffold for more than 25 years, serving a central reverse-turn unit with the inter-ring spacing of about 3.3 Å. A variety ferrocene-peptide conjugates have designed to construct protein secondary structures and demonstrate chirality organization via hydrogen bonding. In general, helical ferrocene moieties in acyclic is induced by absolute configuration ?-carbon atom amino acid adjacent unit. Cyclization regulations restrict conformational flexibility peptide chains, inducing inversion based on reordering bonding interactions. this Minireview article, cyclic focused on. Controlled series adjusting chains through cyclization introduced.